|
| Status |
Public on Dec 31, 2017 |
| Title |
Molecular effects on individual and combined toxicity of OTA and CTN against human embryonic kidney 293 cells |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
We report the transcriptome and miRNAome of human embryonic kidney 293 cells upon the administration of ochratoxin A (OTA) and citrinin (CTN), to compare the individual and combined toxicity of these two mycotoxins. We identified largely differentially expressed miRNAs and corresponding genes, and the correlations between miRNAs and their target genes associated with apoptotic signaling were furthermore analyzed by pmi-RB-REPORT luciferase assay system. We concluded that hsa-miR-1-3p plays an essential role in promoting OTA and CTN-induced renal cytotoxicity.
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| |
|
| Overall design |
Examination of miRNAs with targets and identification of differentially expressed genes in control and mycotoxin-treated human kidney cells.
|
| |
|
| Contributor(s) |
Gong L, Zhu H, Li T, Jiang Y, Duan X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 04, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
HONG ZHU |
| E-mail(s) |
zhuhong@scbg.ac.cn
|
| Phone |
86-15920390530
|
| Organization name |
SOUTH CHINA BOTANICAL GARDEN,CHINESE ACADEMY OF SCIENCES
|
| Street address |
723 XINGKE RD.TIANHE DISDRICT
|
| City |
GUANGZHOU |
| State/province |
GUANGDONG |
| ZIP/Postal code |
510650 |
| Country |
China |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA360136 |
| SRA |
SRP096067 |
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