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| Status |
Public on Jan 16, 2017 |
| Title |
Essential roles of Lamtor1 in CD4+ T cell-mediated autoimmunity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Lamtor1 is a protein that is required for amino acid sensing and activation of mechanistic target of rapamycin complex 1 (mTORC1) at lysosomes. The critical role of Lamtor1 in macrophage polarization has been clarified recently. However, the role of Lamtor1 in adaptive immune system has not been investigated. Here we show that Lamtor1-deficient T cells showed markedly reduced IL-2 production, decreased mTORC1 activity, and decreased expression of purine-synthesis and lipid-synthesis enzymes.
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| Overall design |
The labeled cRNAs were hybridized on 4X44K ver.2 Agilent Whole Mouse Genome dual colour Microarrays (G4846A) in a dye swap experiment.
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| Contributor(s) |
Hosokawa T, Kimura T, Okuzaki D, Kumanogoh A |
| Citation(s) |
28768723 |
| |
| Submission date |
Dec 27, 2016 |
| Last update date |
Jan 19, 2018 |
| Contact name |
Daisuke Okuzaki |
| E-mail(s) |
dokuzaki@biken.osaka-u.ac.jp
|
| Phone |
+81-6-6879-4935
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| Organization name |
Osaka univ.
|
| Department |
Immunology Frontier Research Center
|
| Lab |
Human Immunology （Single Cell Genomics)
|
| Street address |
Yamadaoka 3-1
|
| City |
Suita |
| State/province |
Osaka |
| ZIP/Postal code |
565-0871 |
| Country |
Japan |
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| Platforms (1) |
| GPL10333 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version) |
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| Samples (2) |
| GSM2440843 |
WT(cy3) vs KO(cy5) biological replicate 1 |
| GSM2440844 |
KO(cy3) vs WT(cy5) biological replicate 1 dyeswap |
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| Relations |
| BioProject |
PRJNA359121 |
