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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 29, 2017 |
| Title |
Tsc2 KO cells have a transcriptional signature found in bladder tumors with TSC1/2 deficiency and that is corrected by sirolimus and includes Lgals3 overexpression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Use RNA-seq to obtain transcriptional signature of Tsc2 KO neonatal mouse dermal fibroblasts +/- sirolimus. The resulting mTORC1 transcriptional signature is tested in the TCGA database of bladder cancers with non-silent mutations in TSC1/2.
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| Overall design |
n = 3 WT vehicle, n = 3 KO vehicle, n = 3 WT sirolimus, n = 3 KO sirolimus
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| Contributor(s) |
Klover PJ, Thangapazham RL, Kato J, Wang J, Anderson SA, Hoffmann V, Steagall WK, Li S, McCart E, Nathan N, Bernstock J, Wilkerson MD, Dalgard CL, Moss J, Darling T |
| Citation(s) |
28695825 |
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| Submission date |
Dec 19, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Thomas Darling |
| E-mail(s) |
thomas.darling@usuhs.edu
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| Phone |
301-295-3820
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| Organization name |
Uniformed Services University of the Health Sciences
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| Department |
Dermatology
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| Lab |
Thomas Darling
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| Street address |
4301 Jones Bridge Road
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20814 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA358080 |
| SRA |
SRP095359 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE92589_expressionValues.csv.gz |
805.4 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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