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| Status |
Public on Dec 23, 2002 |
| Title |
Proteomic view of the Plasmodium falciparum life cycle |
| Organism |
Plasmodium falciparum 3D7 |
| Experiment type |
Other
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| Summary |
The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite. We characterized four stages of the parasite life cycle (sporozoites, merozoites, trophozoites and gametocytes) by multidimensional protein identification technology. Functional profiling of over 2,400 proteins agreed with the physiology of each stage. Unexpectedly, the antigenically variant proteins of var and rif genes, defined as molecules on the surface of infected erythrocytes, were also largely expressed in sporozoites. The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression.
Keywords: ordered
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| Web link |
http://www.plasmodb.org/
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| Contributor(s) |
Florens L, Washburn MP, Raine JD, Anthony RM, Grainger M, Haynes JD, Moch JK, Muster N, Sacci JB, Tabb DL, Witney AA, Wolters D, Wu Y, Gardner MJ, Holder AA, Sinden RE, Yates JR, Carucci DJ |
| Citation(s) |
12368866 |
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| Submission date |
Nov 08, 2002 |
| Last update date |
Feb 23, 2012 |
| Contact name |
Laurence Florens |
| E-mail(s) |
florens@scripps.edu
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| Phone |
858-784-8876
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| Organization name |
The Scripps Research Institute
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| Department |
Department of Cell Biology
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| Street address |
SR-11, 10550 North Torrey Pines Road
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| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
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| Platforms (1) |
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| Samples (4)
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| GSM2579 |
Life cycle stage - gametocyte |
| GSM2580 |
Life cycle stage - merozoite |
| GSM2581 |
Life cycle stage - sporozoite |
| GSM2582 |
Life cycle stage - trophozoite |
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| Relations |
| BioProject |
PRJNA85479 |
| Supplementary data files not provided |
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