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Series GSE90889 Query DataSets for GSE90889
Status Public on Jan 25, 2017
Title Expression data for hiPSC-derived RPE treated with 10mM Nicotinamide or vehicle
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We did the RNA-seq analysis to examine the global impact of Nicotinamide (NAM) on hiPSC-derived RPE transcriptome in order to better understand the mechanism of action of NAM. NAM inhibited the expression of Age related Macular degeneration (AMD) associated protein transcripts in hiPSC-derived RPE.
Overall design Seven hiPSC-RPE lines (4 AMD donors and 3 Control donors) that had been cultured with 10mM NAM or vehicle for three weeks were used for RNA extraction and RNA-seq analysis. We treated 4 AMD hiPSC-RPE and 3 Control hiPSC-RPE lines with 10mM NAM or vehicle.
Contributor(s) Saini JS, Kiehl TR, Temple S
Citation(s) 28132833
Submission date Dec 05, 2016
Last update date May 15, 2019
Contact name Thomas R Kiehl
Phone 518-694-8188
Organization name Neural Stem Cell Institute
Street address One Discovery Drive
City Rensselaer
State/province NY
ZIP/Postal code 12144
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (14)
GSM2417021 hiPSC-RPE 1 (AMD 1) vehicle
GSM2417022 hiPSC-RPE 1 (AMD 1) NAM
GSM2417023 hiPSC-RPE 2 (AMD 2) vehicle
BioProject PRJNA356283
SRA SRP094572

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Supplementary file Size Download File type/resource
GSE90889_geo_hiPSC-RPE_Vehicle_vs_NAM.xlsx 6.0 Mb (ftp)(http) XLSX
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