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Series GSE90889 Query DataSets for GSE90889
Status Public on Jan 25, 2017
Title Expression data for hiPSC-derived RPE treated with 10mM Nicotinamide or vehicle
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We did the RNA-seq analysis to examine the global impact of Nicotinamide (NAM) on hiPSC-derived RPE transcriptome in order to better understand the mechanism of action of NAM. NAM inhibited the expression of Age related Macular degeneration (AMD) associated protein transcripts in hiPSC-derived RPE.
 
Overall design Seven hiPSC-RPE lines (4 AMD donors and 3 Control donors) that had been cultured with 10mM NAM or vehicle for three weeks were used for RNA extraction and RNA-seq analysis. We treated 4 AMD hiPSC-RPE and 3 Control hiPSC-RPE lines with 10mM NAM or vehicle.
 
Contributor(s) Saini JS, Kiehl TR, Temple S
Citation(s) 28132833
Submission date Dec 05, 2016
Last update date May 15, 2019
Contact name Thomas R Kiehl
E-mail(s) tomkiehl@neuralsci.org
Phone 518-694-8188
Organization name Neural Stem Cell Institute
Street address One Discovery Drive
City Rensselaer
State/province NY
ZIP/Postal code 12144
Country USA
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (14)
GSM2417021 hiPSC-RPE 1 (AMD 1) vehicle
GSM2417022 hiPSC-RPE 1 (AMD 1) NAM
GSM2417023 hiPSC-RPE 2 (AMD 2) vehicle
Relations
BioProject PRJNA356283
SRA SRP094572

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE90889_geo_hiPSC-RPE_Vehicle_vs_NAM.xlsx 6.0 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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