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Series GSE90726 Query DataSets for GSE90726
Status Public on Jun 21, 2018
Title RNA sequencing of ESC/iPSC-derived purified PAX6-GFP neural progenitors form control and Phelan-Mcdermid patients
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The goal of this study was to generated and transcriptionally analyze purified populations of Phelan-McDermid and control pluripotent stem cells-derived neural progenitors. This type of analysis allowed us to identify prevoisly unknown transcriptional phenotypic changes in patient neural progenitors which appear to be independent of functional synapses.
Overall design Patient and control pluripotent stem cells were targeted by CRISPR/Cas9 and a PAX6-GFP reporter plasmid. Correctly modified clones were selected and subsequently differentiated into PAX6 expressing neural progenitors.
Contributor(s) Jaenisch R, Roessler R
Citation(s) 30456368
Submission date Nov 30, 2016
Last update date May 15, 2019
Contact name Reinhard Roessler
Organization name Whitehead Institute
Street address 455 Main street
City Cambridge
ZIP/Postal code 02142
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (6)
GSM2411266 WIBR3_PAX6-GFP_unsorted
GSM2411267 WIBR3_PAX6-GFP_positive
GSM2411268 WIBR3_PAX6-GFP_negative
BioProject PRJNA355605
SRA SRP094413

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE90726_RAW.tar 7.3 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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