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Series GSE90550 Query DataSets for GSE90550
Status Public on Jul 08, 2017
Title Genome-wide Mapping and Analysis of Aryl Hydrocarbon Receptor (AHR) and Aryl Hydrocarbon Receptor Repressor (AHRR) by ChIP-Seq
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary In this study, we compared the genome-wide binding profiles of AHR and AHRR in MCF-7 human breast cancer cells treated for 24 h with TCDD using chromatin immunoprecipitation followed by next generation sequencing (ChIP-Seq). Overall, this study reveals that AHR and AHRR exhibit similar but also distinct genome-wide binding profiles, supporting the notion that AHRR is a context- and gene-specific repressor of AHR activity.
 
Overall design MCF7 treated with DMSO (vehicle) or TCDD for 24h; ChIP-seq in triplicates using AHR- and AHRR-specific antibodies with Illumina HiSeq 2500
 
Contributor(s) Yang SY, Ahmed S, Matthews J
Citation(s) 28681081
Submission date Nov 26, 2016
Last update date May 15, 2019
Contact name Jason Matthews
Organization name University of Oslo
Department Department of Nutrition, Institute of Basic Medical Sciences
Lab 2201
Street address 1046 Blindern
City Oslo
ZIP/Postal code 0372 Oslo
Country Norway
 
Platforms (2)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (6)
GSM2406722 AHR_DMSO_24h_ChIPSeq
GSM2406723 AHR_TCDD_24h_ChIPSeq
GSM2406724 AHRR_DMSO_24h_ChIPSeq
Relations
BioProject PRJNA355002
SRA SRP093977

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE90550_AHR-only_bound_peaks.txt.gz 43.7 Kb (ftp)(http) TXT
GSE90550_AHRR-only_bound_peaks.txt.gz 17.2 Kb (ftp)(http) TXT
GSE90550_AHR_AHRR_cobound_peaks.txt.gz 16.8 Kb (ftp)(http) TXT
GSE90550_TCDD_DMSO_AHRR_24h_peaks_summary.xlsx 297.0 Kb (ftp)(http) XLSX
GSE90550_TCDD_DMSO_AHR_24h_peaks_summary.xlsx 406.6 Kb (ftp)(http) XLSX
GSE90550_TCDD_DMSO_AHR_45min_peaks_summary.xlsx 2.1 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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