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| Status |
Public on Nov 14, 2016 |
| Title |
Differential gene expression analysis of WT and p190-B-/- HSC after bone marrow transplantation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The overall goals are these experiments are to identify genes and pathways that are critical for hematopoietic stem cell functions during bone marrow regeneration after transplantation. We have found that loss of expression of p190-B RhoGAP, a negative regulator of RhoGTPase, enhances HSC long-term engraftment. Hence, we used microarray analysis to compare gene exprssion profile of WT and p190-B-/- HSC after transplantation.
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| |
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| Overall design |
Expression profiles of mRNA in HSCs from WT and p190-B-/- transplanted mice
|
| |
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| Contributor(s) |
Hinge A, Aronow B, Filippi M |
| Citation(s) |
28176763 |
| |
| Submission date |
Nov 13, 2016 |
| Last update date |
Jun 26, 2019 |
| Contact name |
Marie-Dominique Filippi |
| E-mail(s) |
marie-dominique.filippi@cchmc.org
|
| Phone |
513-636-0991
|
| Organization name |
Cincinnati Children's Research Foundation
|
| Department |
Experimental Hematology and Cancer Biology
|
| Street address |
3333 Burnet Av
|
| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10333 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version) |
|
| Samples (6)
|
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| Relations |
| BioProject |
PRJNA353313 |
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