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Series GSE89249 Query DataSets for GSE89249
Status Public on Jan 31, 2017
Title Advax, a delta inulin microparticle, potentiates in-built adjuvant property of co-administered vaccines
Organism Mus musculus
Experiment type Expression profiling by array
Summary Gene expression data from mouse organs after Advax injection
Advax, an inulin-derived microparticle, has been developed as an adjuvant for several vaccines. Advax is a unique class of adjuvant which can potentiate the endogenous adjuvant effect of the vaccines through a not yet fully-identified, unique mechanisms of action.
 
Overall design C57BL/6J mice (6 week old, male, n = 2 or 3) were injected i.d. or i.p. with a total volume of 1000ug of Advax in PBS. The vehicle-control mice (n = 2 or 3) were injected with the same volume of PBS. After 6 h, the inguinal LNs, liver, kidney and spleen were removed (within one hour for all samples) and grobal gene expression was obtained by Affymetrix GeneChip.
 
Contributor(s) Hayashi M, Aoshi T, Haseda Y, Kobiyama K, Wijaya E, Nakatsu N, Igarashi Y, Standley DM, Yamada H, Honda-Okubo Y, Hara H, Saito T, Takai T, Coban C, Petrovsky N, Ishii KJ
Citation(s) 27919753
Submission date Oct 27, 2016
Last update date Feb 11, 2019
Contact name Yoshinobu Igarashi
E-mail y-igarashi@nibiohn.go.jp
Organization name National Institutes of Biomedical Innovation, Health and Nutrition
Lab Toxicogenomics-Informatics Lab
Street address 7-6-8 Asagi-Saito
City Ibaraki
State/province Osaka
ZIP/Postal code 567-0085
Country Japan
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (40)
GSM2362901 Advax, id, 6hr, lymph node, biological replicate 1
GSM2362902 Advax, id, 6hr, lymph node, biological replicate 2
GSM2362903 Vehicle control, id, 6hr, lymph node, biological replicate 1
Relations
BioProject PRJNA350829

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE89249_RAW.tar 140.2 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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