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| Status |
Public on Jan 31, 2017 |
| Title |
Regulatory Role of SLFN5 in Type I Interferon Signaling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We provide evidence that a member of the IFN-regulated member of the Schlafen (SLFN) family of proteins, SLFN5, promotes the malignant phenotype in glioblastoma multiforme (GBM). Our studies demonstrate that SLFN5 negatively regulates expression of key interferon stimulated genes (ISGs) that mediate important biological functions, including anti-viral and antineoplastic responses.
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| Overall design |
Total RNA was isolated from untreated and IFNβ-treated U87MG SLFN5 WT and U87MG SLFN5 KO human glioblastoma cell lines. Cells were treated for 6 hours with or without human IFNβ (5000 IU/ml).
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| Contributor(s) |
Arslan D, Lisowski P, Platanias LC |
| Citation(s) |
28671669 |
| |
| Submission date |
Oct 14, 2016 |
| Last update date |
May 31, 2019 |
| Contact name |
Pawel Lisowski |
| E-mail(s) |
pawel.lisowski@mdc-berlin.de
|
| Phone |
+493094061370
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| Organization name |
Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association
|
| Street address |
Hannoversche Str. 28
|
| City |
Berlin |
| ZIP/Postal code |
10115 |
| Country |
Germany |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA348531 |
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