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| Status |
Public on Oct 01, 2016 |
| Title |
Small RNA Sequencing of mouse amygdala after knockdown of miR-15a |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. We report that exposing mice to chronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex, and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. Here, we performed small RNA Sequencing of mouse basolateral amygdala after miR15a knockdown using injection of a miR-15a sponge virus or control sponge virus.
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| Overall design |
Small RNA Sequencing of basolateral amygdala of 5 mice injected with a miR-15a sponge virus and 5 mice injected with a control sponge virus.
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| Contributor(s) |
Volk N, Engel M, Binder EB, Chen A |
| Citation(s) |
27829158 |
| |
| Submission date |
Sep 30, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Mareen Engel |
| E-mail(s) |
mareen_engel@psych.mpg.de
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| Organization name |
Max-Planck-Institute of Psychiatry
|
| Department |
Stress Neurobiology and Neurogenetics
|
| Street address |
Kraepelinstr. 2-10
|
| City |
Munich |
| ZIP/Postal code |
80804 |
| Country |
Germany |
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| Platforms (1) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA345045 |
| SRA |
SRP090706 |
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