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Series GSE8730 Query DataSets for GSE8730
Status Public on Aug 10, 2007
Title Effects of TGF-β1 on expression profile of human pulp and odontoblasts
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Transforming growth factor beta 1 (TGF-β1) is the most extensively studied growth factor in dentin-pulp complex, with pleiotropic effects on pulp response and healing. Our main objective was to analyze the expression profile of pulp tissue and odontoblasts, and the effects of TGF-β1 on these profiles in cultured human pulp and odontoblasts with a specific interest in the anti- and pro-inflammatory cytokines.
Keywords: Response to TGF-β1 treatment
Overall design Pulp tissues and odontoblasts were cultured for different time periods, and microarray was performed to both cultured and native samples to detect the effects of TGF-β1. Expression of various interleukins (IL) were confirmed by RT-PCR, and in +/- TGF-β1 treated pulps also by antibody array.
Contributor(s) Pääkkönen V, Vuoristo JT, Salo T, Tjäderhane L
Citation(s) 17889552
Submission date Aug 09, 2007
Last update date Jan 08, 2019
Contact name Virve Pääkkönen
Organization name University of Oulu
Department Institute of Dentistry
Street address Aapistie 3
City Oulu
ZIP/Postal code 90014
Country Finland
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (12)
GSM216537 1h -TGF-beta odontoblasts
GSM216538 1h +TGF-beta odontoblasts
GSM216539 24h -TGF-beta odontoblasts
BioProject PRJNA101987

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8730_RAW.tar 82.2 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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