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| Status |
Public on Jul 06, 2017 |
| Title |
Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Long noncoding RNAs (lncRNAs) mediate important epigenetic regulation in a wide range of biological processes and diseases. We applied comprehensive analyses of RNA-seq and CAGE-seq (cap analysis of gene expression and sequencing) to characterize the dynamic changes in lncRNA expression in rhesus macaque (Macaca mulatta) brain in four representative age groups. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age and sex specificities. Spatiotemporal- and sex-biased changes in lncRNA expression were generally higher than those observed in mRNA expression. A negative correlation between lncRNA and mRNA expression in cerebral cortex was observed and functionally validated. Our findings offer a fresh insight into spatial-, age- and sex-biased changes in lncRNA expression in macaque brain, and suggest that the changes represent a previously unappreciated regulatory system that potentially contributes to brain development and ageing.
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| Overall design |
Examination of 8 different brain regions in Rhsesu Macaque across the four ages (1-, 4-, 10- and 20-year old )
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| Citation(s) |
28687705, 32681011 |
| |
| Submission date |
Sep 21, 2016 |
| Last update date |
Jul 27, 2020 |
| Contact name |
Dong Chen |
| Organization name |
ABLife, Inc.
|
| Department |
Center for Genome Analysis
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| Street address |
388 GaoXin 2nd Road, East Lake Hi-Tech Development Zone
|
| City |
Wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430075 |
| Country |
China |
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| Platforms (2) |
| GPL14954 |
Illumina HiSeq 2000 (Macaca mulatta) |
| GPL21120 |
Illumina NextSeq 500 (Macaca mulatta) |
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| Samples (128)
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| This SuperSeries is composed of the following SubSeries: |
| GSE85377 |
Spatiotemporal- and sex-specific Dynamics of lncRNA expression links to brain development and aging in Rhesus Macaque (RNA-seq) |
| GSE87176 |
Spatiotemporal- and sex-specific Dynamics of lncRNA expression links to brain development and aging in Rhesus Macaque (CAGE-seq) |
|
| Relations |
| BioProject |
PRJNA343790 |
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