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Series GSE85628 Query DataSets for GSE85628
Status Public on Dec 15, 2016
Title Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Heterozygous mutations in GATA4 cause congenital heart defects and cardiomyopathy through unknown mechanisms. To gain insights into the genome-wide localization perturbations during human cardiac development due to GATA4 heterozygosity, we performed ChIP-seq of wildtype and GATA4-G296S diseased cardiomyocytes.
Overall design ChIP sequencing of GATA4, TBX5, MED1, H3K4me3, H3K36me3, H3K27ac, H3K27me3, plus input, from 75 wildtype or diseased pluripotent stem cell derived cardiomyocytes
Contributor(s) Ang Y, Srivastava D
Citation(s) 27984724
Submission date Aug 15, 2016
Last update date May 15, 2019
Contact name Yen-Sin Ang
Organization name Gladstone Institute, UCSF
Street address 1650 Owens Street
City san francisco
State/province CALIFORNIA
ZIP/Postal code 94158
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (75)
GSM2279955 1_8_Gata4_chip
GSM2279957 1_8_H3K27ac_chip
GSM2279958 1_8_H3K27me3_chip
This SubSeries is part of SuperSeries:
GSE85631 Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis
BioProject PRJNA339028
SRA SRP082271

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE85628_Hdac2_d15_peaks.narrowPeak.gz 153.5 Kb (ftp)(http) NARROWPEAK
GSE85628_RAW.tar 52.1 Mb (http)(custom) TAR (of BED, BROADPEAK, NARROWPEAK)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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