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Series GSE8515 Query DataSets for GSE8515
Status Public on Sep 15, 2007
Title Identification of IL-1 and IL-6-responsive genes in human monocyte-derived macrophages
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Using whole-genome Affymetrix microarrays (HG-U133A), we characterized the transcriptome profile of cultured human macrophages stimulated for 4 h with interleukin 1 (IL-1) or interleukin 6 (IL-6). We found that, in distinction to liver cells, IL-1 is much more potent than IL-6 in modifying macrophage gene expression, although considerable heterogeneity in response of macrophages deriving from individual blood donors was observed. The obtained results permitted to identify a large number of cytokine-responsive genes. coding for proteins of unknown function that are now being studied in our laboratory. They may represent novel targets in the anti-inflammatory therapy.
Keywords: Cytokine response
Overall design Analysis of the transcriptome of human monocyte-derived macrophages stimulated in vitro by low doses of IL-1 or IL-6.
Contributor(s) Koj A, Jura J, Korostynski M, Piechota M
Citation(s) 18498781
Submission date Jul 18, 2007
Last update date Aug 10, 2018
Contact name Marcin Piechota
Phone (+4812) 6623328
Organization name Institute of Pharmacology PAS
Department Molecular Neuropharmacology
Street address Smetna 12
City Krakow
ZIP/Postal code 31-343
Country Poland
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (15)
GSM211500 Control, Rep1
GSM211501 Control, Rep2
GSM211502 Control, Rep3
BioProject PRJNA101635

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Supplementary file Size Download File type/resource
GSE8515_RAW.tar 31.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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