|
| Status |
Public on Jul 27, 2016 |
| Title |
Effect of from Human Umbilical Vein Endothelial Cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We profiled global gene expression in primary human umbilical vein endothelial cells to determine the gene expression changes associated with knocking down PKM2 and p53. We identified a p53 dependent transcriptional response that remodels metabolism in cells lacking p53, thus limiting cell growth.
|
| |
|
| Overall design |
Human Umbilical Vein Endothelial Cells were transfected with siRNA duplexes targeting PKM2 and / or p53, RNA was extracted and subjected to RNA sequencing
|
| |
|
| Contributor(s) |
Stone O, Stainier D |
| Citation(s) |
30301887 |
| |
| Submission date |
Jul 26, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Oliver Andrew Stone |
| E-mail(s) |
oliver.stone@mpi-bn.mpg.de
|
| Phone |
+4960327051302
|
| Organization name |
Max Planck Institute
|
| Department |
Developmental Genetics
|
| Lab |
Stainier
|
| Street address |
Ludwigstr 43
|
| City |
Bad Nauheim |
| ZIP/Postal code |
61231 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA335410 |
| SRA |
SRP079926 |
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