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Series GSE84871 Query DataSets for GSE84871
Status Public on Apr 18, 2018
Title MicroRNA biomarkers of tissue function
Organism Bos taurus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary In recent years circulating miRNAs have been proposed as biomarkers of several diseases in humans. However the origin of these potential biomarkers is not always investigated and recent studies have highlighted the importance of selecting biomarkers which are not blood-cell derived to ensure robust performance. The aim of this study was identify circulating miRNAs which are not blood-cell derived (highly expressed in plasma compared to whole blood cells in cow) and investigate the expression of a selection of those in a range of bovine tissues as a follow-up to these results.
Overall design In this experiment a total of 8 bovine samples (4 blood cell samples and 4 plasma samples) were analysed using Illumina miRNA sequencing. These samples were collected from healthy cycling heifers during a normal oestrous cycle from each of 4 animals (the samples are paired). Therefore this study included 4 biological replicates for each of the two groups analysed.
Contributor(s) Ioannidis J, Donadeu X
Citation(s) 29636028
Submission date Jul 26, 2016
Last update date May 15, 2019
Contact name Jason Ioannidis
Organization name The Roslin Institute
Department Developmental Biology
Lab Xavier Donadeu
Street address Easter Bush Veterinary Campus
City Easter Bush
State/province Midlothian
ZIP/Postal code EH25 9RG
Country United Kingdom
Platforms (1)
GPL15749 Illumina HiSeq 2000 (Bos taurus)
Samples (8)
GSM2252914 BC_46
GSM2252915 BC_47
GSM2252916 BC_45
BioProject PRJNA335398
SRA SRP079920

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE84871_processed_data.xlsx 121.9 Kb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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