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| Status |
Public on Feb 16, 2018 |
| Title |
Gene expression data from MGH-U3 following FGFR3 knock-down using FGFR3 siRNAs |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To better understand the molecular mechanisms underlying altered-FGFR3 oncogenic activity in bladder carcinomas, we made use of MGH-U3 cell lines, which were derived from a human bladder tumor and endogenously expressed a mutated activated form of FGFR3 (FGFR3-Y375C), the growth and transformation of these cell lines being dependent on activated-FGFR3 activity. We conducted a gene expression analysis using Affymetrix DNA arrays in this cell line treated or not with FGFR3 siRNAs.
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| Overall design |
MGH-U3 cells were transfected or not with siRNA FGFR3. mRNA was extracted after 72h and gene expression analysis was assessed using the Human Exon 1.0 ST (Affymetrix) array
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| Contributor(s) |
Dufour F, Plassard D, Chapeaublanc E, Bernard-Pierrot I, Gentien D |
| Citation(s) |
29463565 |
| |
| Submission date |
Jul 22, 2016 |
| Last update date |
May 18, 2018 |
| Contact name |
Elodie chapeaublanc |
| E-mail(s) |
elodie.chapeaublanc@pasteur.fr
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| Organization name |
Institut Curie
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| Department |
UMR 144
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| Lab |
Equipe Radvanyi
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| Street address |
26 rue d'ulm
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| City |
paris |
| ZIP/Postal code |
75248 |
| Country |
France |
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| Platforms (1) |
| GPL15236 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [CDF: Brainarray Version 12.1.0] |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA330970 |
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