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| Status |
Public on Jul 31, 2017 |
| Title |
Effect of chronic MDPV on striatal gene expression |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
The bath salt constituent 3,4-methylenedioxypyrovalerone (MDPV) is often detected in blood of patient’s presenting at emergency rooms with a psychosis-like syndrome involving agitation, panic, confusion/cognitive impairment, violent behavior, depression, and other adverse behavioral symptoms. The mechanisms underlying MDPV’s behavioral disturbances and its effect on brain gene expression patterns, particularly effects of chronic use on genetic changes in striatum and cortex are unknown. Such changes in gene expression are expected to reflect altered changes in brain function and structure as a consequence of MDPV abuse. A major objective of these experiments is to determine the relationship between repeated MDPV exposure and genes encoding dopaminergic, vascular, central inflammatory markers (e.g., IL6, IL10, IL1β, IFNγ, TNFα), particularly in prefrontal cortex, striatum, hypothalamus, and amygdala.
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| Overall design |
3 treatment groups: saline, single MDPV/acute, repeated MDPV/chronic (n = 6 per group)
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| Contributor(s) |
Martyniuk CJ, Febo M, Pompilus M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Jul 19, 2016 |
| Last update date |
Nov 13, 2022 |
| Contact name |
Christopher Martyniuk |
| E-mail(s) |
cmartyn@ufl.edu
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| Phone |
3523173905
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| Organization name |
University of Florida
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| Street address |
8891 SW 79th Avenue
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| City |
Gainesville |
| State/province |
FL |
| ZIP/Postal code |
32608 |
| Country |
USA |
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| Platforms (1) |
| GPL22145 |
Agilent-074036 SurePrint G3 Rat GE v2 8x60K Microarray G4858A (Feature Number version) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA330545 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE84596_RAW.tar |
307.8 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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