 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Oct 01, 2018 |
| Title |
Mouse model of RHOA G17V mutation in Peripheral T-Cell Lymphoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive lymphoid tumor derived from malignant transformation of T follicular helper (Tfh) cells. Genetically, AITL is characterized by loss of function mutations in the Ten-Eleven Translocation 2 (TET2) epigenetic tumor suppressor and a highly recurrent mutation (p.Gly17Val, G17V) in the RHOA small GTPase gene
Moreover, RHOA G17V expression in Tet2 deficient hematopoietic progenitors resulted in the specific development of lymphoid tumors resembling human AITL.
Notably, inhibition of ICOS signaling impaired the growth of RHOA G17V-induced mouse lymphomas in vivo, thus providing a potential new rational approach for the treatment of AITL.
|
| |
|
| Overall design |
We analyzed mRNA expression profiles of primary tumor cells expressing Rhoa G17V or Rhoa wild type.
|
| |
|
| Contributor(s) |
Rodriguez-Cortes J, da Silva Almeida AC, Kim CS, West Z, Couronne L, Ambesi-Impiombato A, Belver L, Bhagat G, Bernard O, Ferrando A, Palomero T |
| Citation(s) |
29398449, 33928261 |
| Submission date |
Jun 30, 2016 |
| Last update date |
May 06, 2021 |
| Contact name |
Alberto Ambesi-Impiombato |
| Organization name |
Columbia University
|
| Department |
ICG
|
| Street address |
1130 St. Nicholas Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA327428 |
| SRA |
SRP077667 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE83918_RAW.tar |
4.2 Mb |
(http)(custom) |
TAR (of CSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
|
|
|
|
 |
Less...
More...