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Series GSE83864 Query DataSets for GSE83864
Status Public on Jul 08, 2016
Title Gene Expression Network Analyses in Response to Air Pollution Exposures in the Trucking Industry
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To investigate the cellular responses induced by air pollution exposures, we performed genome-wide gene expression microarray analysis using whole blood RNA sampled at three time-points across the work weeks of 63 non-smoking employees in the trucking industry. Our objective was to identify the genes and gene networks differentially activated in response to micro-environmental measures of occupational exposure to three pollutants: PM2.5 (particulate matter ≤ 2.5 microns in diameter) and elemental carbon (EC) and organic carbon (OC).
 
Overall design Subjects were recruited from 10 trucking terminals in the northeastern US. The participants included workers whose job duties were characterized by different patterns of exposure: pick-up and delivery (P&D) drivers, dock workers, and office workers. Whole blood samples were collected using PaxGene RNA tubes, three times from each subject: (1) before the first shift of the workweek (first day, AM draw); (2) at the end of the first shift (8-12 hours later) on the same day (first day, PM draw); and (3) at the end of the last work shift of the same workweek (last day, PM draw). Micro-environmental samples of PM2.5, and EC and OC in PM1.0 were collected over the full workweek (24 hours/day for 6-9 days) at each of the 10 terminals. The final data set included 165 samples from 63 subjects.
 
Contributor(s) Chu J, Hart JE, Chhabra D, Garshick E, Raby BA, Laden F
Citation(s) 27809917
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 ES016284 BIOMARKERS OF EXPOSURE AND EFFECT IN A TRAFFIC EXPOSED POPULATION BRIGHAM AND WOMEN'S HOSPITAL Laden
Submission date Jun 29, 2016
Last update date Aug 13, 2018
Contact name Jen-hwa Chu
E-mail jen-hwa.chu@yale.edu
Organization name Yale University School of Medicine
Department Pulmonary, Critical Care and Sleep Medicine
Street address PO Box 208057
City New Haven
State/province CT
ZIP/Postal code 06520
Country USA
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (165)
GSM2219928 ST-01000529_S-001045310_5988071029_G
GSM2219929 ST-01000529_S-001045368_5988071029_H
GSM2219930 ST-01000529_S-001045378_5988071029_I
Relations
BioProject PRJNA327228

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE83864_RAW.tar 26.2 Mb (http)(custom) TAR
GSE83864_supplementaryData.Rdata.gz 255.8 Mb (ftp)(http) RDATA
Raw data included within Sample table
Processed data included within Sample table
Processed data is available on Series record

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