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Series GSE81510 Query DataSets for GSE81510
Status Public on Mar 01, 2017
Title Glucocorticoid Receptor: MegaTrans Switching Mediates Repression of ERα-Regulated Transcriptional Program [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The mechanisms underlying GR-dependent inhibition of ERα-regulated gene activation programs at the global genomic level have been poorly understood. We found the binding of GR in trans on ERα-activated enhancers results in gene and enhancer repression by disassembling the MegaTrans Complex.
Overall design All ChIP-Seq experiments were designed to elucidate the mechanism involving GR-mediated repression of ERα-Regulated Transcriptional Program
Contributor(s) Yang F, Ma Q
Citation(s) 28475868
Submission date May 17, 2016
Last update date May 15, 2019
Contact name Qi Ma
Organization name UCSD
Street address 9500 Gilman Dr,
City San Diego
ZIP/Postal code 92093
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (16)
GSM2154984 ChIP-Seq ERα plus ICI
GSM2154985 ChIP-Seq ERα plus ICI and Dex
GSM2154986 ChIP-Seq ERα plus E2
This SubSeries is part of SuperSeries:
GSE81512 Glucocorticoid Receptor: MegaTrans Switching Mediates Repression of ER?-Regulated Transcriptional Program
BioProject PRJNA321838
SRA SRP075269

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE81510_RAW.tar 2.6 Gb (http)(custom) TAR (of BIGWIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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