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Series GSE81440 Query DataSets for GSE81440
Status Public on Jun 24, 2016
Title Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Expression profiling by high throughput sequencing
Summary To investigate the role of NKX3.1 in prostate differentiation, we employed transcriptome analysis of mouse seminal vesicle (from 15-month-old Nkx3.1+/+ mice); mouse prostate (from 4-month-old Nkx3.1+/+ and Nkx3.1-/- mice); human prostate cells (RWPE1 cells engineered with empty vector (altered pTRIPZ), NKX3.1 wild type over-expression, and NKX3.1 (T164A) mutant over-expression); and tissue recombinants (generated from combining engineered mouse epithelial cells (seminal vesicle epithelial cells or prostate epithelial cells from 2-month-old mice) and rat UGS mesenchymal cells). Mouse tissue or human cells were snap frozen for subsequent molecular analysis.

This SuperSeries is composed of the SubSeries listed below.
 
Overall design Refer to individual Series
 
Citation(s) 27339988
Submission date May 13, 2016
Last update date May 15, 2019
Contact name Antonina Mitrofanova
E-mail(s) mitrofanova.antonina@hotmail.com
Organization name Rutgers University
Street address 65 Bergen Street, Rm 923B
City Newark
State/province NJ
ZIP/Postal code 07107
Country USA
 
Platforms (3)
GPL81 [MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (52)
GSM2131441 Nkx3.1 +/+ Seminal Vesicle, 3577sv
GSM2131442 Nkx3.1 +/+ Seminal Vesicle, 3578sv
GSM2131443 Nkx3.1 +/+ Seminal Vesicle, 5253sv
This SuperSeries is composed of the following SubSeries:
GSE80600 Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_15M_SV_Affy)
GSE81424 Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_4M-Prostate_RNA-Seq)
GSE81432 Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_Recomb_RNA-Seq)
Relations
BioProject PRJNA321537

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE81440_RAW.tar 10.7 Mb (http)(custom) TAR (of CEL)

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