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| Status |
Public on Jun 07, 2016 |
| Title |
Comparative cistromics reveals genomic crosstalk between FOXA1 and ERα in tamoxifen-associated endometrial carcinomas |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Tamoxifen, which is used to treat breast cancer, increases the risks of endometrial cancer. In this study, we performed a genome-wide assessment of ERα-chromatin interactions in surgical specimens obtained from patients with tamoxifen-associated endometrial cancer. ERα was found at active enhancers in endometrial cancer cells as marked by the presence of RNA polymerase II and the histone marker H3K27Ac. Our results define conserved sites for genomic interplay between FOXA1 and ERα in breast cancer and tamoxifen-associated endometrial cancer.
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| Overall design |
Binding sites were mapped of Estrogen Receptor alpha (ERa) and FOXA1 in five tamoxifen-associated endometrial carcinoma's (tumor A, tumor B, tumor C tumor D and tumor E). Biological replicated were produced for tumor B.
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| Contributor(s) |
Droog M, Nevedomskaya E, Kim Y, Flach KD, Zwart W |
| Citation(s) |
27197147 |
| |
| Submission date |
May 06, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Marjolein Droog |
| Organization name |
the Netherlands Cancer Institute
|
| Department |
Molecular Pathology
|
| Lab |
Zwart
|
| Street address |
Plesmanlaan 121
|
| City |
Amsterdam |
| State/province |
Noord-Holland |
| ZIP/Postal code |
1066CX |
| Country |
Netherlands |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (23)
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| Relations |
| BioProject |
PRJNA320891 |
| SRA |
SRP074493 |
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