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| Status |
Public on May 06, 2016 |
| Title |
Activation of Inflammation and Metabolic Networks in Age-related Thymic Involution. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Genetic modeling of thymic involution has demonstrated the importance of individual inflammatory pathways affecting the thymic microenvironment, particularly thymic epithelial cells (TEC). We studied the pathogenic processes in chronological aging of the murine thymus. We used microarrays to elucidate the global gene expression and to identify a leading edge subset of age-associated genes in TEC. Analyses of the TEC transcriptome demonstrated altered expression associated with inflammatory and fatty acid metabolism.
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| Overall design |
TECs were FACS sorted from different age of mice (6 weeks, 7 months and 15 months old) for RNA extraction and hybridization on Affymetrix microarrays. Each cohort sample derived from 3-5 mice.
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| Contributor(s) |
Weinberg KI, Min D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 05, 2016 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Kenneth Weinberg |
| E-mail(s) |
kw1@stanford.edu
|
| Phone |
650-725-9249
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| Organization name |
Stanford University
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| Department |
Pediatrics
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| Lab |
Pediatric Stem Cell Transplantation
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| Street address |
1291 Welch Road, G3040
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
95405 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA320761 |
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