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| Status |
Public on Jun 06, 2016 |
| Title |
Transcriptome analysis of patient-derived xenograft models of HER2+ breast cancer brain metastases |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To gain insights into tumor heterogeneity in anti-cancer drug responses of patient-derived xenograft models of HER2+ breast cancer brain metastases, we performed transcriptome gene expression profiling by Ion AmpliSeq™ Transcriptome sequencing that targets more than 20,000 human genes. Our data found that all anti-cancer drugs responders have significantly higher expression levels of AKT-mTOR-dependent signature genes as compared to the non-responders, suggesting that most HER2+ breast cancer brain metastases are depend on the AKT-mTOR pathway
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| Overall design |
Gene expression profiles of five PDX samples were generated by Ion AmpliSeq Transcriptome sequencing, in duplcate, using Ion torrent Proton machine.
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| |
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| Contributor(s) |
Zhao J, Ni J, Xie S |
| Citation(s) |
27270588 |
| |
| Submission date |
Apr 27, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Jean Zhao |
| E-mail(s) |
Jean_zhao@dfci.harvard.edu
|
| Organization name |
Dana Farber Cancer Institute
|
| Department |
Cancer Biology
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| Lab |
Jean Zhao
|
| Street address |
450 Brookline Ave, SM936
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17303 |
Ion Torrent Proton (Homo sapiens) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA319811 |
| SRA |
SRP074069 |
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