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Series GSE80182 Query DataSets for GSE80182
Status Public on Jun 09, 2016
Title A TGFbeta-PRMT5-MEP50 Axis Regulates Cancer Cell Invasion through Histone H3 and H4 Arginine Methylation Coupled Transcriptional Activation and Repression
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We sequenced mRNA from 3 biological replicates each of A549 lung adenocarcinoma cell lines expressing shRNA against GFP (control), PRMT5, or MEP50. We then determined differential gene expression.
 
Overall design Transcriptome analysis of mRNA testing the role of PRMT5 and MEP50 by knockdown in A549 human lung adenocarcinoma cells
Web link http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2016205a.html
 
Contributor(s) Chen H, Shechter D
Citation(s) 27270440
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 GM108646 PRMT5-MEP50 Histone Arginine Methylation in Early Development ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. Shechter
Submission date Apr 12, 2016
Last update date May 15, 2019
Contact name David Shechter
E-mail(s) david.shechter@einstenmed.org
Organization name Albert Einstein College of Medicine
Department Biochemistry
Lab Shechter Lab
Street address 1300 Morris Park Ave
City Bronx
State/province New York
ZIP/Postal code 10461
Country USA
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (9)
GSM2114336 A549_GFPkd_1
GSM2114337 A549_GFPkd_2
GSM2114338 A549_GFPkd_3
Relations
BioProject PRJNA318251
SRA SRP073189

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE80182_A549-PRMT5-MEP50-GFP-HTSeq-count_out.txt.gz 457.9 Kb (ftp)(http) TXT
GSE80182_MEP50kd-htseq-DEp005_DESeq2+edgeR.tsv.gz 335.0 Kb (ftp)(http) TSV
GSE80182_PRMT5kd-htseq-DEp005-DESeq2+edgeR.tsv.gz 333.6 Kb (ftp)(http) TSV
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Raw data are available in SRA
Processed data are available on Series record

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