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Series GSE79754 Query DataSets for GSE79754
Status Public on Dec 06, 2016
Title Chromatin immunoprecipitation and sequencing of pPLT2::PLT2-YFP in the root of plt1plt2 double mutant
Organism Arabidopsis thaliana
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Organ formation in animals and plants relies on precise control of cell state transitions to turn stem cell daughters into fully differentiated cells. In plants, cells cannot rearrange due to shared cell walls. Thus, differentiation progression and the accompanying cell expansion must be tightly coordinated. PLETHORA (PLT) transcription factor gradients were shown to guide the progression of cell differentiation at different positions in the Arabidopsis root. While well-described transcription factor gradients in animals specify distinct cell fates within an essentially static context, the PLT gradient is unique in its ability to control cell differentiation in a growing organ during continuous production and expansion of cells. To understand the output of these gradients we studied the gene set transcriptionally controlled by PLTs. Our work reveals how the PLT gradient regulates cell state by region-specific induction of cell proliferation genes and repression of differentiation. Moreover, PLT targets include major patterning genes and autoregulatory feedback components, reinforcing their role as master regulators of organ development.
Overall design Two replicates were performed for the IP and sequenced along with the Input DNA.
Contributor(s) Santuari L
Citation(s) 27920338
Submission date Mar 31, 2016
Last update date May 15, 2019
Contact name Luca Santuari
Organization name Wageningen University
Department Plant Sciences Group
Lab Plant Developmental Biology
Street address Droevendaalsesteeg 1
City Wageningen
ZIP/Postal code 6708PB
Country Netherlands
Platforms (1)
GPL10088 AB SOLiD System 3.0 (Arabidopsis thaliana)
Samples (3)
GSM2102042 PLT2_IP1
GSM2102043 PLT2_IP2
GSM2102044 input DNA
This SubSeries is part of SuperSeries:
GSE79755 The PLETHORA gene regulatory network guides growth and cell differentiation in Arabidopsis roots
BioProject PRJNA316934
SRA SRP072664

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE79754_PLT2_IP1_IP2_pooled.wig.gz 3.6 Mb (ftp)(http) WIG
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Raw data are available in SRA
Processed data are available on Series record

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