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Series GSE79453 Query DataSets for GSE79453
Status Public on Oct 10, 2016
Title Arabidopsis FORGETTER1 sustains stress-induced transcription through nucleosome remodeling
Organism Arabidopsis thaliana
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Plants as sessile organisms can adapt to environmental stress to mitigate its adverse effects. As part of such adaptation they maintain an active memory of heat stress for several days that mediates a more efficient response to recurring stress. We identified a mutant that is specifically affected in this heat stress memory. The forgetter1 (frg1) mutant is defective in the Arabidopsis orthologue of Strawberry notch and displays reduced maintenance of heat-induced gene expression. FRG1 globally associates with the promoter region of actively expressed genes in a heat-dependent fashion. FRG1 interacts with chromatin remodelers of the SWI/SNF and ISWI families, which also display reduced heat stress memory. Accordingly, nucleosome dynamics at loci with altered maintenance of heat-induced expression are affected in frg1. Thus, FRG1 is required to sustain a transcription-competent chromatin environment by nucleosome positioning. Our findings suggest a mechanism for the highly conserved Strawberry notch proteins in development and pathologies.
Overall design Chromatin binding of FRG1.
Contributor(s) Brzezinka K, Altmann S, Czesnick H, Nicolas P, Benke E, Kabelitz T, Kappel C, Bäurle I
Citation(s) 27680998
Submission date Mar 21, 2016
Last update date May 15, 2019
Contact name Isabel Bäurle
Phone +49 331 9772647
Organization name Universität Potsdam
Department Institut für Biochemie und Biologie
Street address Karl-Liebknecht-Str. 24-25
City Potsdam
ZIP/Postal code 14476
Country Germany
Platforms (1)
GPL17639 Illumina HiSeq 2500 (Arabidopsis thaliana)
Samples (12)
GSM2095552 35S::FRG1-YFP_ACC_R1
GSM2095553 35S::FRG1-YFP_ACC_R2
GSM2095554 35S::FRG1-YFP_ACC_R3
BioProject PRJNA315864
SRA SRP072125

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE79453_RAW.tar 647.1 Mb (http)(custom) TAR (of BEDGRAPH)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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