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| Status |
Public on Mar 15, 2016 |
| Title |
microRNA expression in facet cartilage degeneration |
| Platform organisms |
Homo sapiens; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human betaherpesvirus 6B; Human gammaherpesvirus 8; Merkel cell polyomavirus; Betapolyomavirus hominis; Betapolyomavirus macacae |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Osteoarthritis (OA) of spine (facet joints; FJ) is one of the major causes of severe low back pain and disability worldwide. The degeneration of facet cartilage is a hallmark of FJ OA. However, endogenous mechanisms that initiate degeneration of facet cartilage are unknown and there are no disease-modifying therapies to stop FJ OA. In this study we performed microRNA array analysis to identify differentially expressed microRNAs in facet cartilage from patients with FJ OA compared to facet cartilage from patients with lumbar disc herniation (LDH).
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| Overall design |
4 samples analyzed, 2 cartilage samples from patients with LDH (control). In FJ OA group two samples were analyzed. Each sample comprised of pooled cartilage samples from n=3 FJ OA patients.
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| Contributor(s) |
Nakamura A, Rampersaud YR, Sharma A, Lewis SJ, Wu B, Datta P, Sundrarajan K, Rossomacha E, Jurisica I, Kapoor M |
| Citation(s) |
27699225 |
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| Submission date |
Mar 15, 2016 |
| Last update date |
Oct 06, 2016 |
| Contact name |
Akihiro Nakamura |
| E-mail(s) |
ashmode930@gmail.com
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| Organization name |
University Health Network
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| Department |
Genetics and Development
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| Street address |
60 Leonard Avenue
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| City |
Toronto |
| ZIP/Postal code |
M5T2S8 |
| Country |
Canada |
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| Platforms (1) |
| GPL21599 |
miRCURY LNA microRNA Array, 7th generation, miRBase 20 (Gene ID version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA315290 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE79258_RAW.tar |
11.8 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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