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| Status |
Public on Jul 01, 2020 |
| Title |
Gene expression after treatment in a 3D lung tumor model in comparison to conventional 2D cell culture |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression of a 3D model for the treatment of EGFR mutated lung tumors (HCC827 cell line, sensitive to gefitinib, and A549 cells, insensitive to gefitinib) was analysed and compared to the same treatment effects in the cell lines when cultured under 2D conditions.
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| Overall design |
Global expression profiling of two culture conditions, two treatment groups in two cell lines differing in EGFR activating mutation status.
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| Contributor(s) |
Schmitt M, Scholz CJ, Walles H, Dandekar G, Nietzer S |
| Citation missing |
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| Submission date |
Mar 10, 2016 |
| Last update date |
Jul 02, 2020 |
| Contact name |
Claus Juergen Scholz |
| Organization name |
University Hospital Würzburg
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| Department |
Core Unit SysMed
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| Street address |
Josef-Schneider-Str. 2
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| City |
Würzburg |
| ZIP/Postal code |
97080 |
| Country |
Germany |
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| Platforms (1) |
| GPL16043 |
GeneChip® PrimeView™ Human Gene Expression Array (with External spike-in RNAs) |
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| Samples (8)
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| GSM2084931 |
A549 cells, 3D-cultured, control-treated |
| GSM2084932 |
A549 cells, 3D-cultured, gefitinib-treated |
| GSM2084933 |
HCC827 cells, 3D-cultured, control-treated |
| GSM2084934 |
HCC827 cells, 3D-cultured, gefitinib-treated |
| GSM2084935 |
A549 cells, 2D-cultured, control-treated |
| GSM2084936 |
A549 cells, 2D-cultured, gefitinib-treated |
| GSM2084937 |
HCC827 cells, 2D-cultured, control-treated |
| GSM2084938 |
HCC827 cells, 2D-cultured, gefitinib-treated |
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| Relations |
| BioProject |
PRJNA314883 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE79078_RAW.tar |
22.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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