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Status |
Public on Aug 28, 2016 |
Title |
Single cell transcriptome analysis of mouse thoracic sympathetic ganglia |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
We explore the heterogeneity of mouse thoracic ganglia demonstrating the presence of an unexpected variety of cell-types and identify specialized populations of nipple- and pilo-erector muscle neurons. These neurons extend axonal projections and are born amongst other neurons during embryogenesis, but remain unspecialized until target organogenesis occurs postnatally. Target innervation and cell-type specification is coordinated by an intricate acquisition of unique combinations of growth factor receptors and the initiation of expression of concomitant ligands by the nascent erector muscles.
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Overall design |
RNA-seq analysis of 298 single sympathetic neuronal cells from the mouse thoracic ganglion
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Contributor(s) |
Furlan A, La Manno G, Linnarsson S, Ernfors P |
Citation(s) |
27571008 |
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Submission date |
Mar 02, 2016 |
Last update date |
May 15, 2019 |
Contact name |
Sten Linnarsson |
Organization name |
Karolinska Institutet
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Department |
Medical Biochemistry and Biophysics
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Lab |
Molecular Neurobiology
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Street address |
Scheeles väg 1
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City |
Stockholm |
ZIP/Postal code |
171 65 |
Country |
Sweden |
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Platforms (1) |
GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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Samples (298)
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Relations |
BioProject |
PRJNA314132 |
SRA |
SRP071085 |