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Series GSE7793 Query DataSets for GSE7793
Status Public on Oct 23, 2008
Title Vancomycin nephrotoxicity assessed by DNA microarray
Organism Mus musculus
Experiment type Expression profiling by array
Summary The glycopeptide antibiotic vancomycin (VCM) represents one of the last lines of defense against methicillin-resistant Staphylococcus aureus infections. However, vancomycin is nephrotoxic, but the mechanism of toxicity is still unclear.
The goal of this study was twofold: (1) gain insights into the molecular mechanisms of vancomycin nephrotoxicity at the genomic level and (2) evaluate potential biomarkers (gene expression profiles) of vancomycin-induced kidney injury
Keywords: Dose response
 
Overall design Groups of 6 female BALB/c mice were treated with 7 daily iv or ip doses of vancomycin (50, 200, and 400 mg/kg) or saline, and sacrificed on Day 8
 
Contributor(s) Dieterich C, Ng H
Citation(s) 18930951
Submission date May 14, 2007
Last update date Feb 11, 2019
Contact name Hanna Hongchin Ng
E-mail hanna.ng@sri.com
Organization name SRI International
Street address 333 Ravenswood Avenue
City Menlo Park
State/province CA
ZIP/Postal code 94025
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (48)
GSM189045 Kidney_saline iv_mouse #001
GSM189047 Kidney_saline iv_mouse #002
GSM189048 Kidney_saline iv_mouse #003
Relations
BioProject PRJNA99821

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7793_RAW.tar 176.8 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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