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Series GSE7756 Query DataSets for GSE7756
Status Public on Feb 13, 2008
Title Genetic variation in Glp1r expression influences the rate of gastric emptying
Organism Mus musculus
Experiment type Expression profiling by array
Summary A C57BL6/J (B6) x CAST/Ei (CAST) strain intercross has revealed a new quantitative trait locus (QTL) on Chromosome (Chr) 17 controlling total food volume (Tfv1; LOD=7.6). Compared with B6, the CAST mice consume 39% more food volume per body weight in a macronutrient diet selection paradigm. Linkage analyses of total food volume revealed the presence of suggestive QTL on Chrs 2, 6, and 15 and a significant locus on Chr 17. An interval-specific congenic strain, B6.CAST-17, was then developed which verified the QTL. Microarray analysis of stomach in congenic and wildtype B6 mice revealed Glp1r as an expression candidate with physiological relevance to food intake. Further functional analysis of this gene revealed this gene as potential candidate for total food volume trait in mice
Keywords: Comparative gene expression analysis
Overall design RNA obtained from six male B6.CAST-17 homozygous congenic mice and six male wild type B6 mice. Each strain was represented by two pools, each containing equal amounts of RNA from three animals, for a total of four samples. Thus, two biological replicates were analyzed for each strain.
Contributor(s) Kumar KG, Smith-Richards BK
Citation(s) 18077508
Submission date May 07, 2007
Last update date Mar 16, 2012
Contact name Brenda Richards
Organization name Pennington Biomedical Research Center
Department Basic Science
Lab Genetics of Eating Behavior
Street address 6400 Perkins Rd.
City Baton Rouge
State/province LA
ZIP/Postal code 70808
Country USA
Platforms (1)
GPL2995 ABI Mouse Genome Survey Microarray
Samples (4)
GSM187689 Stomach - Congenics - 1
GSM187691 Stomach - Congenics - 2
GSM187692 Stomach - Wildtype - 1
BioProject PRJNA99881

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