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Series GSE77098 Query DataSets for GSE77098
Status Public on Jul 17, 2016
Title Haemopedia: An Expression Atlas of Murine Haematopoietic Cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary Haematopoiesis is a multi-stage process that involves the differentiation of multipotent stem cells and progenitor cells into distinct mature cell lineages. Here we present Haemopedia, a comprehensive atlas of murine gene expression data that covers all the mature lineages in haematopoiesis, including rare cell populations such as eosinophils, mast cells, basophils and megakaryocytes and a large collection of progenitor and stem cells. We have used this dataset to identify gene sets with specifically enriched expression in each of the mature blood cell lineages. Many of the genes in these sets show conserved lineage-enriched expression patterns in human haematopoiesis. We also identify some genes with divergent expression patterns between mouse and human, highlighting species specific differences in blood cell production. To make analyses of Haemopedia and other blood cell transcriptional datasets easier, we have created an online web portal, Haemosphere, which provides simple tools to interrogate gene expression-based relationships between haematopoietic cell types and genes of interest.
 
Overall design Total RNA was obtained from 54 haematopoetic cells types and 8 non-haematopoietic out groups.
 
Contributor(s) de Graaf CA, Choi J, Baldwin TM, Hilton DJ
Citation(s) 27499199
Submission date Jan 21, 2016
Last update date Jan 16, 2019
Contact name Carolyn de Graaf
E-mail degraaf@wehi.edu.au
Phone 61393452602
Organization name Walter and Eliza Hall Institute
Lab Hilton Lab
Street address 1G Royal Pde Parkville
City Melbourne
State/province Victoria
ZIP/Postal code 3052
Country Australia
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (203)
GSM2043909 GMP-1
GSM2043910 MEP-1
GSM2043911 EffCD4T-1
Relations
BioProject PRJNA309431

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE77098_RAW.tar 15.8 Mb (http)(custom) TAR
GSE77098_non-normalized.txt.gz 37.0 Mb (ftp)(http) TXT
GSE77098_readme.txt.gz 1.0 Kb (ftp)(http) TXT
Raw data is available on Series record
Processed data included within Sample table

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