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Series GSE76893 Query DataSets for GSE76893
Status Public on Oct 24, 2016
Title FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The Mediator and Cohesin complexes control the cellular transcriptional program. However, it is not well understood how they are recruited to regulatory regions. Our study shows that the core transcriptional regulatory circuitry of cancer cells is essential to recruit Mediator, Cohesin and NIPBL to enhancer and promoter regions of actively transcribed genes in cancer cells.
Overall design ChIP-seq analysis of Mediator (MED1), Cohesin (SMC1A) and NIPBL in HEPG2, A549 and MCF7 cells. The analysis also includes ChIP-Seq data for the transcription factor ERa in MCF7 cells treated with estradiol.
Contributor(s) Fournier M, Bourriquen G, Lamaze FC, Fournier É, Bilodeau S
Citation(s) 27739523
Submission date Jan 14, 2016
Last update date May 15, 2019
Contact name Steve Bilodeau
Phone 418 525-4444 15550
Organization name Centre de recherche du CHU de Québec
Street address 9 McMahon
City Quebec
State/province Quebec
ZIP/Postal code G1R 2J6
Country Canada
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (26)
GSM2040024 HEPG2_ChIP_NIPBL_A301-779A_NA_NA_Rep1
GSM2040025 HEPG2_ChIP_MED1_A300-793A_NA_NA_Rep1
BioProject PRJNA308868
SRA SRP068482

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Supplementary file Size Download File type/resource
GSE76893_RAW.tar 11.6 Mb (http)(custom) TAR (of NARROWPEAK)
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Raw data are available in SRA
Processed data provided as supplementary file

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