|
| Status |
Public on Jan 12, 2016 |
| Title |
Expression data from QY and QYRC cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We superinfected a hepatocellular carcinoma (HCC) cell line (QGY-7703,QY) with oncolytic parvovirus H1 (H-1PV) and acquired a group of resistant cells QYRC. Previous studies suggested that cells surviving H-1PV superinfection should behave somewhat similarly to normal cells. When compared with the QGY-7703 cells, the QYRC cells indeed exhibited loss of colony formation in soft agar, and they didn’t form detectable tumors after being hypodermically injected into 5 nude mice.
In order to find out what cellular factors may be responsible for the loss of tumor cell phenotype, we compared the cDNA microarray profiles of the QGY-7703 and QYRC cells to find that a series of genes were upregulated in the H-1PV-resistant QYRC cells
|
| |
|
| Overall design |
We investigated the expression profiles of QY and QYRC cell lines.
|
| |
|
| Contributor(s) |
Wu H, Wang W, Huang J, Ge K, Li G, Huang Q |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 11, 2016 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Huang Qingshan |
| E-mail(s) |
qshuang@fudan.edu.cn
|
| Organization name |
Fudan University
|
| Department |
Genetics
|
| Lab |
State Key Laboratory of Genetics Engineering
|
| Street address |
No 2005, Songhu Road
|
| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200438 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (2) |
|
| Relations |
| BioProject |
PRJNA308501 |
