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Series GSE76381 Query DataSets for GSE76381
Status Public on Oct 06, 2016
Title Single Cell RNA-seq Study of Midbrain and Dopaminergic Neuron Development in Mouse, Human, and Stem Cells
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In order to get a better molecular understanding of human midbrain development, this study defines cell types of the ventral midbrain in both human and mouse as well as stem cell-derived dopaminergic neuron preparations, and reveals the temporal dynamics of key lineages across development and the adult.
 
Overall design Single cells according to Samples list consisting of: Human embryo ventral midbrain cells between 6 and 11 weeks of gestation, mouse ventral midbrain cells at six developmental stages between E11.5 to E18.5, Th+ neurons at P19-P27, and putative dopaminergic neurons at P28-P56 FACS-sorted from Slc6a3-Cre/tdTomato mice. Stem cells (iPSCs and ESCs) preparation at different stages of differentiation towards Th+ neurons.

 
Contributor(s) LaManno G, Gyllborg D, Arenas E, Linnarsson S
Citation(s) 27716510
Submission date Dec 28, 2015
Last update date Mar 17, 2019
Contact name Sten Linnarsson
Organization name Karolinska Institutet
Department Medical Biochemistry and Biophysics
Lab Molecular Neurobiology
Street address Scheeles väg 1
City Stockholm
ZIP/Postal code 171 65
Country Sweden
 
Platforms (2)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (6179)
GSM2268339 1772067089_A01
GSM2268340 1772067089_A02
GSM2268341 1772067089_A03
Relations
BioProject PRJNA307121
SRA SRP067844

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE76381_ESMoleculeCounts.cef.txt.gz 5.9 Mb (ftp)(http) TXT
GSE76381_EmbryoMoleculeCounts.cef.txt.gz 5.3 Mb (ftp)(http) TXT
GSE76381_MouseAdultDAMoleculeCounts.cef.txt.gz 1.0 Mb (ftp)(http) TXT
GSE76381_MouseEmbryoMoleculeCounts.cef.txt.gz 6.1 Mb (ftp)(http) TXT
GSE76381_iPSMoleculeCounts.cef.txt.gz 1001.2 Kb (ftp)(http) TXT
Raw data are available in SRA
Processed data is available on Series record

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