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Series GSE76250 Query DataSets for GSE76250
Status Public on Jan 04, 2016
Title Comprehensive transcriptome profiling reveals multigene signatures in triple negative breast cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To develop and validate novel multigene signatures to facilitate individualized treatment of TNBC patients By integrating expression profiles of messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs).
 
Overall design We analysed 165 TNBC samples and 33 paired normal breast tissues using transcriptome microarrays. Tumor-specific mRNAs and lncRNAs were identified and correlated with patients’ recurrence-free survival (RFS). Using Cox regression model, we built two multigene signatures incorporating mRNAs and lncRNAs. The prognostic and predictive accuracy of the signatures were tested in a training set of 165 TNBC patients and validated in another 101 TNBC patients.
 
Contributor(s) Liu Y, Jiang Y, Xu X, Hu X, Yu K, Shao Z
Citation(s) 26813360, 26921339
Submission date Dec 22, 2015
Last update date Oct 29, 2018
Contact name Yi-Zhou Jiang
E-mail yizhoujiang@fudan.edu.cn
Phone +8615921910483
Organization name Fudan University Shanghai Cancer Center
Street address No. 270 Dong-An Road
City Shanghai
State/province Shanghai
ZIP/Postal code 200032
Country China
 
Platforms (1)
GPL17586 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
Samples (198)
GSM1977646 cancer [1253]
GSM1977647 cancer [1268]
GSM1977648 cancer [1271]
Relations
BioProject PRJNA306725

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE76250_RAW.tar 4.2 Gb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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