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Series GSE75079 Query DataSets for GSE75079
Status Public on Nov 17, 2015
Title Expression data from 3 week old Rat liver (F1)
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Developmental Origins of Health and Disease Hypothesis (DOHaD) all emphasized that maternal nutrition plays an important role on the growth and development of offspring. More and more attention has been paid on the effect of maternal high fat diet and overnutrition during pregnancy on the susceptibility of offspring metabolic diseases. So we aim to build the rat model of maternal high fat diet which may induce steatohepatitis and change of lipid metabolism in the early life of offspring, and explore their possible mechannisms.And then to investigate the influence of maternal high fat diet on the expression of hepatic metabolic genes in the early life of offspring.
We used microarrays to detail the global program of gene expression underlying fatty acid liver and identified distinc distinct classes of up-regulated and down-regulated genes during this process.
 
Overall design Rat liver were selected at 3 week of age for RNA extraction and hybridization on Affymetrix microarrays.We sought to obtain the results we need so we chose the timing of 3 week old (at weaning) offspring in order to emphasize on the possible biochemical mechanisms of maternal effect.
 
Contributor(s) Ye T, Huang Y
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Submission date Nov 17, 2015
Last update date Jul 31, 2017
Contact name Yanhong HUANG
E-mail(s) eyesonu2@163.com
Phone +8613585526102
Organization name Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicne
Street address 1665 Kong Jiang Road
City Shanghai
ZIP/Postal code 200092
Country China
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (6)
GSM1942191 liver at 3 week old of C1, biological rep1
GSM1942192 liver at 3 week old of C2, biological rep1
GSM1942193 liver at 3 week old of C3 ,biological rep1
Relations
BioProject PRJNA302383

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Supplementary file Size Download File type/resource
GSE75079_RAW.tar 15.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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