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Series GSE74928 Query DataSets for GSE74928
Status Public on Mar 26, 2016
Title XX-650-23, an inhibitor of CREB-CBP interaction, effect on acute myeloid leukemia cell line
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary Analysis of acute myeloid leukemia KG1 cells treated with XX-650-23 (5 mM) for 12hrs. XX-650-23 inhibits proliferation of KG1 cells. Results provides insight into the molecular mechanisms underlying by the inhibitory activity of XX-650-23 on acute leukemia.
 
Overall design mRNA profiles of KG1 cells treated with XX-650-23 were generated by deep sequencing.
CREB genome binding profiles of KG1 cells treated with XX-650-23 were generated by deep sequencing.
 
Contributor(s) Mitton B, Chae H, Ferrari R, Sakamoto KM
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Nov 12, 2015
Last update date May 15, 2019
Contact name Kathleen M Sakamoto
E-mail(s) kmsakamoto@stanford.edu
Organization name Stanford University
Department Pediatrics
Street address CCSR 1215C, 235 Campus Drive
City Stanford
State/province California
ZIP/Postal code 94305-5162
Country USA
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (8)
GSM1937937 DMSO rep1
GSM1937938 DMSO rep2
GSM1937939 XX-650-23 rep1
Relations
BioProject PRJNA301935
SRA SRP066087

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74928_RAW.tar 230.0 Kb (http)(custom) TAR (of BED)
GSE74928_XX_RNAseq_rawCounts.txt.gz 185.5 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
Processed data provided as supplementary file

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