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| Status |
Public on Mar 26, 2016 |
| Title |
XX-650-23, an inhibitor of CREB-CBP interaction, effect on acute myeloid leukemia cell line |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Analysis of acute myeloid leukemia KG1 cells treated with XX-650-23 (5 mM) for 12hrs. XX-650-23 inhibits proliferation of KG1 cells. Results provides insight into the molecular mechanisms underlying by the inhibitory activity of XX-650-23 on acute leukemia.
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| |
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| Overall design |
mRNA profiles of KG1 cells treated with XX-650-23 were generated by deep sequencing.
CREB genome binding profiles of KG1 cells treated with XX-650-23 were generated by deep sequencing.
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| |
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| Contributor(s) |
Mitton B, Chae H, Ferrari R, Sakamoto KM |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 12, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Kathleen M Sakamoto |
| E-mail(s) |
kmsakamoto@stanford.edu
|
| Organization name |
Stanford University
|
| Department |
Pediatrics
|
| Street address |
CCSR 1215C, 235 Campus Drive
|
| City |
Stanford |
| State/province |
California |
| ZIP/Postal code |
94305-5162 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA301935 |
| SRA |
SRP066087 |
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