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| Status |
Public on Oct 15, 2015 |
| Title |
Gene expression signatures for IhhN protein induced cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Previous studies demonstrated that hererozygous missense mutations in IHH could lead to a decreasing IHH signaling efficacy and cause brachydactyly type A1 (BDA1). For revealing difference of Gli1-mediated downstream regulatory effects between wild type IHH signaling and E95K mutant IHH signaling, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to be targets of Gli1 cis-regulation.
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| Overall design |
Gene expressions of Wild type IhhN protein-induced or E95K mutant IhhN protein-induced were measured after 48-hour incubation in the presence of 750nM protein. Non-protein induced cells were as control.
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| Contributor(s) |
Shen L, Qin S |
| Citation(s) |
30651074 |
| |
| Submission date |
Oct 14, 2015 |
| Last update date |
Jul 18, 2019 |
| Contact name |
Lu Shen |
| E-mail(s) |
yoyomailer@sjtu.edu.cn
|
| Organization name |
Shanghai Jiao Tong University
|
| Department |
Bio-X Institutes
|
| Lab |
Pharmacogenomics
|
| Street address |
RM 218 Little White House 1954 Huashan RD
|
| City |
Shanghai |
| ZIP/Postal code |
200030 |
| Country |
China |
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| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
|
| Samples (4)
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| GSM1908238 |
mRNA_wild type IhhN induced cells_rep1 |
| GSM1908239 |
mRNA_wild type IhhN induced cells_rep2 |
| GSM1908240 |
mRNA_E95K mutant IhhN induced cells_rep1 |
| GSM1908241 |
mRNA_non-protein induced normal cells_rep1 |
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| This SubSeries is part of SuperSeries: |
| GSE74023 |
Gene expression and Gli1-ChIP in IhhN protein induced cells |
|
| Relations |
| BioProject |
PRJNA298758 |
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