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| Status |
Public on Apr 04, 2016 |
| Title |
Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations [ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. Here, we perform HiC chromosome conformation, ChIP-seq and RNA-seq to investigate how the three-dimensional organization of the cancer genome is disrupted in the context of epigenetic remodelling and atypical gene expression programs.
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| Overall design |
Hi-C, ChIP-seq and RNA-seq were conducted in three human prostate cell lines: normal prostate epithelial cells (PrEC) and prostate cancer cells (PC3 and LNCaP).
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| Contributor(s) |
Taberlay P, Achinger-Kawecka J |
| Citation(s) |
27053337 |
| |
| Submission date |
Oct 06, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Joanna Achinger-Kawecka |
| E-mail(s) |
joanna.achinger@adelaide.edu.au
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| Organization name |
South Australian Immunogenomics Cancer Institute
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| Street address |
AHMS Building, North Terrace
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| City |
Adelaide |
| State/province |
SA |
| ZIP/Postal code |
5005 |
| Country |
Australia |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (3) |
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| This SubSeries is part of SuperSeries: |
| GSE73785 |
Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations |
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| Relations |
| BioProject |
PRJNA297886 |
| SRA |
SRP064525 |
