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Series GSE73573 Query DataSets for GSE73573
Status Public on Dec 28, 2015
Title Expression data for KDM1B knockdown in Glioma-Initiating Cells (GICs)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with glioma initiating cells (GICs) implicated to be critical for tumor progression and resistance to therapy. KDM1B is involved in regulating GICs' responses to hypoxia, since over-expression of KDM1B delays the cell growth under hypoxia while knocking-down of KDM1B in GICs promotes their survival and tumorigenic abilities.
 
Overall design We used RNA-Sequencing to detail the global change of gene expression in GICs with knockdown of KDM1B, and identified de-regulated genes and pathways downstream of KDM1B.
CD133+ D456MG GICs were infected with non-targeting control and shRNA of KDM1B. Then RNA was extracted and gene expression was profiled by RNA-Seq.
 
Contributor(s) Li H, Hu J, Wang X
Citation(s) 26766590
Submission date Sep 29, 2015
Last update date May 15, 2019
Contact name Hai-Ri Li
E-mail(s) hairili@ucsd.edu
Phone 858-534-4926
Organization name University of California, San Diego
Department Medicine
Lab Dr. Francesca Telese
Street address 9500 Gilman Dr.
City La Jolla
State/province CA
ZIP/Postal code 92093
Country USA
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (6)
GSM1898074 D456MG GICs NT rep1
GSM1898075 D456MG GICs NT rep2
GSM1898076 D456MG GICs NT rep3
Relations
BioProject PRJNA297346
SRA SRP064317

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Supplementary file Size Download File type/resource
GSE73573_RNA_seq_raw_count_for_GEO.txt.gz 356.5 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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