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| Status |
Public on Dec 31, 2018 |
| Title |
BAL cell gene expression is predictive of Mortality in Idiopathic Pulmonary Fibrosis and enriched for Genes of Airway Basal Cells (III) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Background: We got interested whether genes of airway basal cells are enriched in sarcoidosis.
Methods: Bronchoscopy with bronchoalveolar lavage (BAL) was performed in 26 patients with sarcoidosis, chest-x-ray type III and IV, and 20 healthy donors and isolated BAL cells.Transcriptome of BAL cells were studied by using Affymetrix Human Affymetrix Whole-Transcript Human Gene 1.0 ST array on an Affymetrix platform. Microarray data were imported, log2-transformed and quantile normalized using robust multi-array average (RMA). We tested enrichment for airway basal cells by global enrichment analysis.
Results: we did not find enrichment of airway basal cell genes in sarcoidosis compared to healthy volunteers.
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| Overall design |
Microarray data of BAL cells from 26 patients with sarcoidosis and 20 healthy volunteers were obtained. We tested for enrichment of genes highly expressed in airway basal cells and identified in GSE70864
Please note that sarcoidosis stage information for each individual patient was not provided since the information was not considered for the statistical data analysis.
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| Contributor(s) |
Prasse A, Violette S |
| Citation(s) |
30141961 |
| |
| Submission date |
Sep 24, 2015 |
| Last update date |
Apr 03, 2019 |
| Contact name |
Antje Prasse |
| Organization name |
Medical School Hannover
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| Department |
Pneumology
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| Lab |
Prasse OE6870
|
| Street address |
Carl-Neubergstrasse 1
|
| City |
Hannover |
| ZIP/Postal code |
30625 |
| Country |
Germany |
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| Platforms (1) |
| GPL10739 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version] |
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| Samples (46)
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| This SubSeries is part of SuperSeries: |
| GSE70867 |
BAL cell gene expression is predictive of Mortality in Idiopathic Pulmonary Fibrosis and enriched for Genes of Airway Basal Cells |
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| Relations |
| BioProject |
PRJNA296875 |
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