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| Status |
Public on Sep 19, 2015 |
| Title |
Transcriptome data of multiple sclerosis patients receiving fingolimod therapy [HTA-2_0, CD8+ cells, exon level] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We analyzed the gene expression patterns of different blood cell types before and during fingolimod treatment in a group of patients with relapsing-remitting multiple sclerosis (RRMS).
Affymetrix Human Transcriptome Arrays (HTA) 2.0 were used to obtain gene expression profiles of immune cell populations from 10 RRMS patients within the first 3 months of fingolimod treatment.
This GEO entry provides the Affymetrix HTA 2.0 microarray data of peripheral blood CD8+ cells, preprocessed according to the exon level workflow.
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| Overall design |
EDTA blood samples were taken from all patients immediately before first and second fingolimod administration as well as after 3 months of therapy.
Total RNA of CD8+ cells positively selected from each blood sample was extracted, labeled and hybridized to high-density Affymetrix HTA 2.0 microarrays to quantify the transcript levels.
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| Contributor(s) |
Hecker M, Koczan D, Zettl UK |
| Citation(s) |
27631876, 29314605, 30040082 |
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| Submission date |
Sep 18, 2015 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Michael Hecker |
| E-mail(s) |
michael.hecker@rocketmail.com
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| Organization name |
University of Rostock
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| Department |
Department of Neurology
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| Lab |
Division of Neuroimmunology
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| Street address |
Gehlsheimer Str. 20
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| City |
Rostock |
| ZIP/Postal code |
18147 |
| Country |
Germany |
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| Platforms (1) |
| GPL17585 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [probe set (exon) version] |
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| Samples (30)
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| GSM1888109 |
Patient 1, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888110 |
Patient 1, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888111 |
Patient 1, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1888112 |
Patient 2, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888113 |
Patient 2, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888114 |
Patient 2, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1888115 |
Patient 3, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888116 |
Patient 3, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888117 |
Patient 3, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1888118 |
Patient 4, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888119 |
Patient 4, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888120 |
Patient 4, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1888121 |
Patient 5, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888122 |
Patient 5, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888123 |
Patient 5, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1888124 |
Patient 6, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888125 |
Patient 6, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888126 |
Patient 6, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1888127 |
Patient 7, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888128 |
Patient 7, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888129 |
Patient 7, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1888130 |
Patient 8, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888131 |
Patient 8, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888132 |
Patient 8, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1888133 |
Patient 9, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888134 |
Patient 9, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888135 |
Patient 9, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1888136 |
Patient 10, CD8+ cells, before first dose of fingolimod [exon-level] |
| GSM1888137 |
Patient 10, CD8+ cells, before second dose of fingolimod [exon-level] |
| GSM1888138 |
Patient 10, CD8+ cells, after 3 months of fingolimod treatment [exon-level] |
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| This SubSeries is part of SuperSeries: |
| GSE73174 |
Transcriptome data of multiple sclerosis patients receiving fingolimod therapy |
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| Relations |
| BioProject |
PRJNA296109 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE73172_RAW.tar |
932.0 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
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