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| Status |
Public on Sep 19, 2015 |
| Title |
Transcriptome data of multiple sclerosis patients receiving fingolimod therapy [HTA-2_0, CD4+ cells, exon level] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We analyzed the gene expression patterns of different blood cell types before and during fingolimod treatment in a group of patients with relapsing-remitting multiple sclerosis (RRMS).
Affymetrix Human Transcriptome Arrays (HTA) 2.0 were used to obtain gene expression profiles of immune cell populations from 10 RRMS patients within the first 3 months of fingolimod treatment.
This GEO entry provides the Affymetrix HTA 2.0 microarray data of peripheral blood CD4+ cells, preprocessed according to the exon level workflow.
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| Overall design |
EDTA blood samples were taken from all patients immediately before first and second fingolimod administration as well as after 3 months of therapy.
Total RNA of CD4+ cells positively selected from each blood sample was extracted, labeled and hybridized to high-density Affymetrix HTA 2.0 microarrays to quantify the transcript levels.
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| Contributor(s) |
Hecker M, Koczan D, Zettl UK |
| Citation(s) |
28155899, 29314605, 30040082 |
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| Submission date |
Sep 16, 2015 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Michael Hecker |
| E-mail(s) |
michael.hecker@rocketmail.com
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| Organization name |
University of Rostock
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| Department |
Department of Neurology
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| Lab |
Division of Neuroimmunology
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| Street address |
Gehlsheimer Str. 20
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| City |
Rostock |
| ZIP/Postal code |
18147 |
| Country |
Germany |
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| Platforms (1) |
| GPL17585 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [probe set (exon) version] |
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| Samples (30)
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| GSM1884983 |
Patient 1, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1884984 |
Patient 1, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1884985 |
Patient 1, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1884986 |
Patient 2, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1884987 |
Patient 2, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1884988 |
Patient 2, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1884989 |
Patient 3, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1884990 |
Patient 3, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1884991 |
Patient 3, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1884992 |
Patient 4, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1884993 |
Patient 4, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1884994 |
Patient 4, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1884995 |
Patient 5, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1884996 |
Patient 5, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1884997 |
Patient 5, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1884998 |
Patient 6, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1884999 |
Patient 6, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1885000 |
Patient 6, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1885001 |
Patient 7, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1885002 |
Patient 7, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1885003 |
Patient 7, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1885004 |
Patient 8, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1885005 |
Patient 8, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1885006 |
Patient 8, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1885007 |
Patient 9, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1885008 |
Patient 9, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1885009 |
Patient 9, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
| GSM1885010 |
Patient 10, CD4+ cells, before first dose of fingolimod [exon-level] |
| GSM1885011 |
Patient 10, CD4+ cells, before second dose of fingolimod [exon-level] |
| GSM1885012 |
Patient 10, CD4+ cells, after 3 months of fingolimod treatment [exon-level] |
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| This SubSeries is part of SuperSeries: |
| GSE73174 |
Transcriptome data of multiple sclerosis patients receiving fingolimod therapy |
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| Relations |
| BioProject |
PRJNA296111 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE73080_RAW.tar |
919.4 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
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