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Series GSE72977 Query DataSets for GSE72977
Status Public on Oct 26, 2015
Title FOXM1 Cistrome Predicts Breast Cancer Metastatic Outcome Better Than FOXM1 Expression Levels or Tumor Proliferation Index [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary FOXM1 is a key transcription factor regulating cell cycle progression, DNA damage response, and a host of other hallmark cancer features, but the role of the FOXM1 cistrome in driving estrogen receptor-positive (ER+) vs. ER- breast cancer clinical outcomes remains undefined.
 
Overall design Chromatin immunoprecipitation sequencing (ChIP-Seq) coupled with RNA sequencing (RNA-Seq) analyses was used to identify FOXM1 target genes in breast cancer cells (MCF-7) where FOXM1 expression was either induced by cell proliferation or repressed by p53 upregulation.
 
Contributor(s) Yau C, Meyer L, Benz S, Vaske C, Scott G, Egan B, Labhart P, Pourmand N, Benz CC
Citation(s) 26456572
Submission date Sep 14, 2015
Last update date May 15, 2019
Contact name Christina Yau
E-mail(s) cyau@buckinstitute.org
Phone 415-209-2248
Organization name Buck Institute of Age Research
Lab Benz Lab
Street address 8001 Redwood Blvd
City Novato
State/province CA
ZIP/Postal code 94945
Country USA
 
Platforms (1)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
Samples (5)
GSM1876186 Proliferating_MCF7
GSM1876187 Confluent_MCF7
GSM1876188 MI63_treated_MCF7
This SubSeries is part of SuperSeries:
GSE73371 FOXM1 Cistrome Predicts Breast Cancer Metastatic Outcome Better Than FOXM1 Expression Levels or Tumor Proliferation Index
Relations
BioProject PRJNA295520
SRA SRP063698

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE72977_RAW.tar 370.0 Kb (http)(custom) TAR (of TXT)
GSE72977_highVsLow_peaks.txt.gz 50.3 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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