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Series GSE72446 Query DataSets for GSE72446
Status Public on Aug 28, 2015
Title Interactions of PfETRAMP14.1 with PfEMP1 and EXP-2 at the parasitophorous vacuolar membrane (PVM) of human malaria parasite Plasmodium falciparum [HIGH PARASITEMIA ANALYSIS]
Platform organisms Plasmodium falciparum; Anopheles gambiae
Sample organism Homo sapiens
Experiment type Expression profiling by array
Summary In our global differential gene expression analyses,ETRAMP14.1, an ETRAMP family member was found to be highly transcribed in vivo in severe
Malaria patients from highly endemic Indian region. This study for the first time reports the interaction of ETRAMP14.1 with PfEMP1, EXP2 and Hsp70-1.
Therefore, we propose that ETRAMP14.1 facilitate PfEMP1 to cross the PVM via transcolon machinery component EXP2.
 
Overall design Peripheral blood samples containing ring forms of the P.falciparum from mild and severe malaria patients were used for RNA extraction, CDNA synthesis and hybridization on Affymetrix microarrays. In vitro ring stage P.falciparum cultures were used for normalization.
 
Contributor(s) Kirthana MV, Ghosh SK, Kumar S, Surolia N
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Submission date Aug 27, 2015
Last update date Aug 29, 2015
Contact name Sanjeev Kumar
E-mail sanjeev@biocosls.in
Organization name BioCOS Life Sciences Pvt Ltd
Department R&D
Lab R&D Bioinformatics
Street address 526/A,19th Main,3-sect,Ganesh Complex (2nd Floor) HSR Layout
City Bangalore
State/province Karnataka
ZIP/Postal code 560102
Country India
 
Platforms (1)
GPL1321 [Plasmodium_Anopheles] Affymetrix Plasmodium/Anopheles Genome Array
Samples (15)
GSM1862800 Control-1: invitro rings
GSM1862801 Control-2: invitro rings
GSM1862802 Control-3: invitro rings
This SubSeries is part of SuperSeries:
GSE72448 Interactions of PfETRAMP14.1 with PfEMP1 and EXP-2 at the parasitophorous vacuolar membrane (PVM) of human malaria parasite Plasmodium falciparum
Relations
BioProject PRJNA294080

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE72446_RAW.tar 27.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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