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| Status |
Public on Sep 09, 2015 |
| Title |
SKBR3 cells treated with epirubicin or hypoxia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Intratumoral heterogeneity may generate a diversity of resistance mechanisms that could cause different therapeutic responses in different cell populations.
Gene expression profiles were generated for breast cancer cells that had survived two different treatment and were also sorted by the cancer stem cell marker CD44.
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| Overall design |
SKBR3 cells were treated with epirubicin or hypoxia, and then flow sorted by CD44 expression and processed for expression profiles. 3 or 4 biological replicates were generated for each condition.
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| Contributor(s) |
O'Brien SK, Chen L, Zhong W, Armellino D, Yu J, Loreth C, Follettie M, Damelin M |
| Citation(s) |
26340918 |
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| Submission date |
Aug 25, 2015 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Christine Loreth |
| E-mail(s) |
christine.loreth@pfizer.com
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| Organization name |
Pfizer
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| Street address |
610 Main St
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| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02139 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (19)
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| GSM1861031 |
Epirubicin treated, CD44-/lo sorted, biological replicate 1 |
| GSM1861032 |
Epirubicin treated, CD44-/lo sorted, biological replicate 2 |
| GSM1861033 |
Epirubicin treated, CD44-/lo sorted, biological replicate 3 |
| GSM1861034 |
Epirubicin treated, CD44-/lo sorted, biological replicate 4 |
| GSM1861035 |
Epirubicin treated, CD44hi sorted, biological replicate 1 |
| GSM1861036 |
Epirubicin treated, CD44hi sorted, biological replicate 2 |
| GSM1861037 |
Epirubicin treated, CD44hi sorted, biological replicate 3 |
| GSM1861038 |
Epirubicin treated, CD44hi sorted, biological replicate 4 |
| GSM1861039 |
Hypoxia treated, CD44-/lo sorted, biological replicate 1 |
| GSM1861040 |
Hypoxia treated, CD44-/lo sorted, biological replicate 2 |
| GSM1861041 |
Hypoxia treated, CD44-/lo sorted, biological replicate 3 |
| GSM1861042 |
Hypoxia treated, CD44-/lo sorted, biological replicate 4 |
| GSM1861043 |
Hypoxia treated, CD44hi sorted, biological replicate 1 |
| GSM1861044 |
Hypoxia treated, CD44hi sorted, biological replicate 2 |
| GSM1861045 |
Hypoxia treated, CD44hi sorted, biological replicate 3 |
| GSM1861046 |
Hypoxia treated, CD44hi sorted, biological replicate 4 |
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| Relations |
| BioProject |
PRJNA295058 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE72362_RAW.tar |
105.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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